A sensitive spectrophotometric method for the determination of sulfonamides in pharmaceutical preparations

Nagaraja, P. and Naik, S. D. and Shrestha, A. K. and Shivakumar, A. (2007) A sensitive spectrophotometric method for the determination of sulfonamides in pharmaceutical preparations. Acta Pharmaceutica, 57 (3). pp. 333-342. ISSN 1846-9558

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Abstract

A new, simple and sensitive spectrophotometric method for the determination of some sulfonamide drugs has been developed. The method is based on the diazotization of sulfacetamide, sulfadiazine, sulfaguanidine, sulfamerazine, sulfamethazine, sulfamethoxazole and their coupling with 8-hydroxyquinoline in alkaline media to yield red coloured products, with absorption maximum at 500 nm. The Beer’s law is obeyed from 0.1-7.0 µg mL-1. The limits of quantification and limits of detection were 0.11-0.18 and 0.03-0.5 µg mL-1, respectively. Intraday precision (RSD 0.1-0.5%) and accuracy (recovery 97.3-100.8) of the developed method were evaluated. No interference was observed from common adjuvants. The method has been successfully applied to the assay of sulpha drug in the pharmaceutical formulations.

Item Type: Article
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: C Swapna Library Assistant
Date Deposited: 25 Sep 2019 09:30
Last Modified: 25 Sep 2019 09:30
URI: http://eprints.uni-mysore.ac.in/id/eprint/8522

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