Kalpana, H. N. and Channu, B. C. and Dass, Chhabil and Houghton, P. J. and Thimmaiah, K. N. (2000) Hydrophobic interactions of phenoxazine modulators with bovine serum albumin. Proceedings of The Indian Academy of Sciences-Chemical Sciences, 112 (1). pp. 51-61. ISSN 0253-4134
Full text not available from this repository. (Request a copy)Abstract
The interaction of 10-(3'-N-morpholinopropyl)phenoxazine MPP], 10-(4'-N-morpholinobutyl)phenoxazine MBP], 10-(3'-N-morpholinopropyl)-2-chlorophenoxazine MPCP], 10-(3'-N-piperidinopropyl)-2-chlorophenoxazine PPCP] or 10-(3'-N-morpholinopropyl)-2-trifluoromethylphenoxazine MPTP] with bovine serum albumin (BSA) has been studied by gel filtration and equilibrium dialysis methods. The binding of these modulators, based on dialysis experiments, has been characterized using the following parameters: percentage of bound drug (beta), the association constant (K-1), the apparent binding constant (k) and the free energy change (Delta F degrees). The binding of phenoxazine derivatives to serum transporter protein, BSA, is correlated with their octanol-water partition coefficient, log(10) P. In addition, effect of the displacing activities of hydroxyzine and acetylsalicylic acid on the binding of phenoxazine derivatives to albumin has been studied. Results of the displacement experiments show that phenoxazine benzene rings and tertiary amines attached to the side chain of the phenoxazine moiety are bound to a hydrophobic area on the albumin molecule.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | phenoxazine; hydrophobic interaction; displacement experiments; bovine serum albumin |
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Department of > Chemistry |
| Depositing User: | Users 19 not found. |
| Date Deposited: | 25 Sep 2019 07:54 |
| Last Modified: | 09 Sep 2022 10:45 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/8517 |
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