Synthesis and characterization of nucleoside derivatives, n-(benzoyl)-n-(deoxyguanosin-8-yl)-4-aminobiphenyl and n-(2′-deoxyguanosin-8-yl)-4-aminobiphenyl via α-phenyl-n-(4-biphenyl)nitrone

Mallesha, H. and Ravi Kumar, K. R. and Rangappa, K. S. (2002) Synthesis and characterization of nucleoside derivatives, n-(benzoyl)-n-(deoxyguanosin-8-yl)-4-aminobiphenyl and n-(2′-deoxyguanosin-8-yl)-4-aminobiphenyl via α-phenyl-n-(4-biphenyl)nitrone. Nucleosides, Nucleotides and Nucleic Acids, 21 (4-5). pp. 385-392. ISSN 1532-2335

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Official URL: https://doi.org/10.1081/NCN-120006832

Abstract

ABSTRACT Lead tetraacetate (LTA) oxidation of α-Phenyl-N-(4-biphenyl)nitrone (8) to give a new ultimate carcinogen, N-acetoxy-N-benzoyl-4-aminobiphenyl (9) which was reacted with deoxyguanosine (dG) at pH 6.9 to give nucleoside derivative, N-(benzoyl)-N-(deoxyguanosin-8-yl)-4-aminobiphenyl (10). Following debenzoylation with sodium carbonate-methanol leads to N-(2′-deoxyguanosin-8-yl)-4-aminobiphenyl (11).

Item Type: Article
Additional Information: PMID: 12182350
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: manjula User
Date Deposited: 25 Sep 2019 06:06
Last Modified: 25 Sep 2019 06:06
URI: http://eprints.uni-mysore.ac.in/id/eprint/8502

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