New hydrogenation catalyst: An advantageous method for the removal of hydrogenolysable protecting groups in peptide synthesis

Channe Gowda, D. and Abiraj, K. and Augustine, Paul (2002) New hydrogenation catalyst: An advantageous method for the removal of hydrogenolysable protecting groups in peptide synthesis. Letters in Peptide Science, 9 (1). pp. 43-47. ISSN 1573-496X

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Official URL: https://doi.org/10.1023/A:1021340718671

Abstract

Removal of some commonly used protecting groups in peptide synthesis by catalytic transfer hydrogenation employing ammonium formate and magnesium is described. This method is equally competitive with other methods in deblocking most of the commonly used protecting groups in peptide synthesis. tert-Butyl derived and base labile protecting groups were completely stable under these conditions. The use of ammonium formate and magnesium makes this a rapid, low-cost alternative to palladium and reduces the work-up to a simple filtration and extraction operation.

Item Type: Article
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: manjula User
Date Deposited: 24 Sep 2019 10:23
Last Modified: 24 Sep 2019 10:23
URI: http://eprints.uni-mysore.ac.in/id/eprint/8472

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