Magnesium/hydrazinium monoformate: A new hydrogenation method for removal of some commonly used protecting groups in peptide synthesis

Channe Gowda, D. (2002) Magnesium/hydrazinium monoformate: A new hydrogenation method for removal of some commonly used protecting groups in peptide synthesis. Tetrahedron Letters, 43 (2). 311 - 313. ISSN 0040-4039

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Official URL: https://doi.org/10.1016/S0040-4039(01)02113-X

Abstract

Removal of some commonly used protecting groups in peptide synthesis by catalytic transfer hydrogenation employing hydrazinium monoformate and magnesium is described. This method is equally competitive with other methods in deblocking most of the commonly used protecting groups in peptide synthesis. tert-Butyl derived and base labile protecting groups were completely stable under these conditions. The use of Mg/NH2–NH2·HCOOH makes this a rapid, low-cost alternative to palladium and reduces the work-up to a simple and extraction operation.

Item Type: Article
Uncontrolled Keywords: catalytic transfer hydrogenation, hydrazinium monoformate, magnesium, new hydrogenation system, peptide synthesis, deprotection
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: manjula User
Date Deposited: 24 Sep 2019 07:51
Last Modified: 24 Sep 2019 07:51
URI: http://eprints.uni-mysore.ac.in/id/eprint/8449

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