Iminodibenzyl as a novel coupling agent for the spectrophotometric determination of sulfonamide derivatives

Nagaraja, P. and Sunitha, K. R. and Vasantha, R. A. and Yathirajan, H. S. (2002) Iminodibenzyl as a novel coupling agent for the spectrophotometric determination of sulfonamide derivatives. European Journal of Pharmaceutics and Biopharmaceutics, 53 (2). 187 - 192. ISSN 1873-3441

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Official URL: https://doi.org/10.1016/S0939-6411(01)00235-1

Abstract

A rapid, selective and simple spectrophotometric method for the determination of sulfa-drugs is described. The method is based on the formation of violet colored azo product by the diazotization of sulfonamides, viz. sulfathiazole (SFT), sulfadiazine (SFD), sulfacetamide (SFA), sulfamethoxazole (SFMx), sulfamerazine (SFMr), sulfaguanidine (SFG) and sulfadimidine (SFDd) followed by a coupling reaction with iminodibenzyl in alcohol medium. Absorbance of the resulting violet azo product is measured at 570–580nm and is stable for 24h at 27°C. Beer's law is obeyed in the concentration range of 0.05–6.0μgml−1 at the wavelength of maximum absorption. The method is successfully employed for the determination of sulfonamides in various pharmaceutical preparations and common excipients used as additives in pharmaceuticals do not interfere in the proposed method. The method offers the advantages of simplicity, rapidity and sensitivity without the need for extraction or heating. A reaction mechanism is proposed for the formation of the violet azo product.

Item Type: Article
Uncontrolled Keywords: Sulfa-drugs, Iminodibenzyl, Diazotization, Spectrophotometry, Pharmaceuticals
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: manjula User
Date Deposited: 24 Sep 2019 05:40
Last Modified: 24 Sep 2019 05:40
URI: http://eprints.uni-mysore.ac.in/id/eprint/8424

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