Oxidation of psychotropic drugs by Chloramine-T in acid medium: a kinetic study using spectrophotometry

Saldanha, R. J. D. and Ananda, S. and Venkatesha, B. M. and Made Gowda, N. M. (2002) Oxidation of psychotropic drugs by Chloramine-T in acid medium: a kinetic study using spectrophotometry. Journal of Molecular Structure, 606 (1). 147 - 154. ISSN 0022-2860

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Official URL: https://doi.org/10.1016/S0022-2860(01)00859-6

Abstract

The kinetics of oxidation of psychotropic drugs, chlorpromazine hydrochloride (CPH) and fluphenazine dihydrochloride (FPH), by Chloramine-T (CAT) in pH 1.6 buffer medium has been studied spectrophotometrically at λmax=570 and 530nm, respectively, at 30°C. The reaction rate shows a fractional-order dependence on CAT and first-order dependence on each substrate. The reaction rate also shows an inverse fractional-order in H+. Additions of halide ions and the reduction product of CAT, p-toluenesulfonamide, and variation of ionic strength and dielectric constant of the medium do not have any significant effect on the reaction rate. The activation parameters for the reaction were evaluated. The proposed general mechanism and the derived rate law are consistent with the observed kinetics.

Item Type: Article
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: manjula User
Date Deposited: 24 Sep 2019 05:27
Last Modified: 24 Sep 2019 05:27
URI: http://eprints.uni-mysore.ac.in/id/eprint/8416

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