A glycoprotein from a folk medicinal plant, Withania somnifera, inhibits hyaluronidase activity of snake venoms

Deepa, K. M. and Girish, K. S. and Gowda, T. Veerabasappa (2006) A glycoprotein from a folk medicinal plant, Withania somnifera, inhibits hyaluronidase activity of snake venoms. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, 143 (2). pp. 158-161.

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Abstract

Venom hyaluronidases help in rapid spreading of the toxins by destroying the integrity of the extra-cellular matrix of the tissues in the victims. A hyaluronidase inhibitor (WSG) is purified from a folk medicinal plant, Withania somnifera. The glycoprotein inhibited the hyaluronidase activity of cobra (Naja naja) and viper (Daboia russelii) venoms, which was demonstrated by zymogram assay and staining of the skin tissues for differential activity. WSG completely inhibited the activity of the enzyme at a concentration of 1 : 1 w/w of venom to WSG. Thus we are able to demonstrate that the glycoprotein inhibits hyaluronidase activity of the venoms. External application of the plant extract as an antidote in rural parts of India to snakebite victims appears to have a scientific basis. (c) 2006 Elsevier Inc. All rights reserved.

Item Type: Article
Uncontrolled Keywords: Withania somnifera; snake venom; hyaluronidase; hyaluronidase inhibitor; glycoprotein; N. naja; D. russelii; extracellular matrix
Subjects: Agriculture Biological Sciences > Biochemistry
University of Mysore > PG Campuses > Manasagangotri, Mysore > Agriculture Biological Sciences > Biochemistry
Divisions: PG Campuses > Manasagangotri, Mysore > Biochemistry
Depositing User: Users 17 not found.
Date Deposited: 03 May 2013 06:11
Last Modified: 11 Sep 2013 06:08
URI: http://eprints.uni-mysore.ac.in/id/eprint/8304

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