A simple spectrophotometric determination of some phenothiazine drugs in pharmaceutical samples

Nagaraja, P. and Dinesh, N. D. and Made Gowda, N. M. and Rangappa, K. S. (2000) A simple spectrophotometric determination of some phenothiazine drugs in pharmaceutical samples. Analytical Sciences, 16 (11). pp. 1127-1131. ISSN 0910-6340

Text (Full Text) Che_2000_Nagaraja.pdf - Published Version Restricted to Registered users only Download (44kB) | Request a copy

Abstract

A new, simple and sensitive spectrophotometric method for the determination of some phenothiazine drugs has been developed. The proposed method is based on the reaction of promethazine hydrochloride (PH), chlorpromazine hydrochloride (CPH), triflupromazine hydrochloride (TPH), fluphenazine hydrochloride (FPH), trifluoperazine hydrochloride (TFPH), perazine dimaleate (PDM) and prochlorperazine maleate (PCPM) with iron(III) and a subsequent reaction with ferricyanide in an acetic acid medium to yield Prussian blue colored product with a maximum absorption at 700-720 nm. The common excipients used as additives in pharmaceuticals do not interfere with the proposed method. Analytical data for determination of the pure compound are presented together with the applications of the proposed method to the analysis of some pharmaceutical formulations. The results compare favorably with those of the official method.

Item Type:	Article
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	Users 19 not found.
Date Deposited:	19 Sep 2019 05:56
Last Modified:	06 Jul 2022 07:47
URI:	http://eprints.uni-mysore.ac.in/id/eprint/8257

Actions (login required)

View Item