Venom from spiders of the genus Hippasa: Biochemical and pharmacological studies

Nagaraju, S. and Mahadeswaraswamy, Y. H. and Girish, K. S. and Kemparaju, K. (2006) Venom from spiders of the genus Hippasa: Biochemical and pharmacological studies. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, 144 (1). pp. 1-9.

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Official URL: http://dx.doi.org/10.1016/j.cbpc.2006.04.016

Abstract

The venoms from female spiders of the genus Hippasa namely H. partita, H. agelenoides and H. lycosina are compared for biochemical and pharmacological properties. SDS-PAGE pattern revealed varied protein composition. Marked variability is seen with casein hydrolyzing enzymes in SDS-PAGE zymogram. H. partita venom was the only venom that hydrolyzed gelatin while the other two venoms did not. The venoms shared similar hyaluronidase activity, showing a single activity band in SDS-PAGE zymogram. The PLA(2) activity varied as H. partita > H. agelenoides > H. lycosina venoms. Marked differences were noted in the ability to induce edema, cytotoxicity, myotoxicity and neurotoxicity, while hemorrhage was associated exclusively with H. partita venom. (c) 2006 Elsevier Inc. All rights reserved.

Item Type: Article
Subjects: Agriculture Biological Sciences > Biochemistry
University of Mysore > PG Campuses > Manasagangotri, Mysore > Agriculture Biological Sciences > Biochemistry
Divisions: PG Campuses > Manasagangotri, Mysore > Biochemistry
Depositing User: Users 17 not found.
Date Deposited: 02 May 2013 03:32
Last Modified: 02 May 2013 03:32
URI: http://eprints.uni-mysore.ac.in/id/eprint/8207

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