2-(2-(2-Ethoxybenzoylamino)-4-chlorophenoxy)-N-(2-ethoxybenzoyl)benzamine inhibits EAT cell induced angiogenesis by down regulation of VEGF secretion

Priya, B. S. and Anil Kumar, C. and Nanjunda Swamy, S. and Basappa and Naveen, S. and Shashidhara Prasad, J. and Rangappa, K. S. (2007) 2-(2-(2-Ethoxybenzoylamino)-4-chlorophenoxy)-N-(2-ethoxybenzoyl)benzamine inhibits EAT cell induced angiogenesis by down regulation of VEGF secretion. Bioorganic & Medicinal Chemistry Letters, 17 (10). 2775 - 2780. ISSN 0960-894X

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Official URL: https://doi.org/10.1016/j.bmcl.2007.02.074

Abstract

Compounds containing amide bond play a pivotal role in various pharmaceutical applications. 2-(2-(2-Ethoxybenzoylamino)-4-chlorophenoxy)-N-(2-ethoxybenzoyl)benzamine 4 is shown to be a potent antiangiogenic agent. In this study, we report the microwave-assisted synthesis, single crystal X-ray structure, and antiangiogenic effect of compound 4 in EAT cell induced angiogenesis. Treatment with compound 4 in vivo demonstrated down regulation of the secretion of VEGF in EAT cells and inhibition of blood vessel formation indicating the potential angioinhibitory effect of the compound in EAT cells.

Item Type: Article
Uncontrolled Keywords: Amide, Benzamine, Antiangiogenic effect, EAT cell, VEGF
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: MUL SWAPNA user
Date Deposited: 16 Sep 2019 10:04
Last Modified: 16 Nov 2019 10:07
URI: http://eprints.uni-mysore.ac.in/id/eprint/8172

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