An efficient synthesis of 2-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)morpholine: a potent M1 selective muscarinic agonist

Sunil Kumar, Y. C. and Sadashiva, M. P. and Rangappa, K. S. (2007) An efficient synthesis of 2-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)morpholine: a potent M1 selective muscarinic agonist. Tetrahedron Letters, 48 (26). 4565 - 4568. ISSN 0040-4039

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Official URL: https://doi.org/10.1016/j.tetlet.2007.04.135

Abstract

2-(1-Methyl-1,2,5,6-tetrahydropyridin-3-yl)morpholine is useful for synthesizing potent antimicrobials including the arecoline derivatives, phendimetrazine and polygonapholine and was synthesised in nine steps with an overall yield of 36. Bromination of 3-acetylpyridine and dehydration of a diol with cyclization were pivotal to the success of the strategy.

Item Type: Article
Uncontrolled Keywords: C-Substituted morpholines, 2-Acetyl pyridine, Arecoline
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: C Swapna Library Assistant
Date Deposited: 16 Sep 2019 05:27
Last Modified: 16 Sep 2019 05:27
URI: http://eprints.uni-mysore.ac.in/id/eprint/8141

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