Evaluation of new pyrazole derivatives for their biological activity: Structure-activity relationship

Jayaroopa, P. and Vasanth Kumar, G. and Renuka, N. and Harish Nayaka, M. A. and Ajay Kumar, K. (2013) Evaluation of new pyrazole derivatives for their biological activity: Structure-activity relationship. International Journal of PharmTech Research, 5 (1). pp. 264-270. ISSN 0974-4304

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Abstract

A series of new 3-Aryl-4-(4-methoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole-5-carbonitriles (1) were screened in vitro for their antibacterial and antifungal activities against four different organisms. The minimal inhibitory concentration (MIC's) was determined against each organism. The compounds were tested for their antioxidant activity and reducing power ability. The effect of substitution on the activity, and the 0possible structure activity relationship mechanism of the compounds for their antioxidant activity are presented.

Item Type: Article
Uncontrolled Keywords: article, controlled study, drug screening, nonhuman, 1, 1 diphenyl 2 picrylhydrazyl, antioxidant activity, unclassified drug, antibacterial activity, antifungal activity, Aspergillus flavus, Aspergillus niger, Bacillus subtilis, Candida albicans, Escherichia coli, minimum inhibitory concentration, Salmonella typhimurium, Staphylococcus aureus, structure activity relation, in vitro study, Fusarium oxysporum, pyrazole derivative
Subjects: C Chemical Science > Chemistry
Divisions: Yuvaraj college > Chemistry
Depositing User: Arshiya Kousar
Date Deposited: 12 Sep 2019 07:14
Last Modified: 12 Sep 2019 07:14
URI: http://eprints.uni-mysore.ac.in/id/eprint/8051

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