Fusaric acid, a mycotoxin, and its influence on blood coagulation and platelet function

Devaraja, S. and Girish, K. S. and Santhosh, M. S. and Hemshekhar, M. and Nayaka, S. C. and Kemparaju, K. (2013) Fusaric acid, a mycotoxin, and its influence on blood coagulation and platelet function. Blood Coagulation and Fibrinolysis, 24 (4). pp. 419-423.

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Official URL: http://doi.org/10.1097/MBC.0b013e32835d548c

Abstract

The current study intended to explore the effect of fusaric acid on blood coagulation including plasma coagulation and platelet aggregation. Fusaric acid exhibited biphasic effects on citrated human plasma recalcification time. At concentrations below 50 ng, fusaric acid decreased the clotting time of plasma dose-dependently from 130 = 3s control value to 32 = 3s; however, above 50 ng, fusaric acid increased the clotting time from 32 = 3s and reached a maximum of 152âŠs at 100 ng and remained unaltered thereafter for the increased dose of fusaric acid. Fusaric acid without damaging red blood cells and platelets, inhibited agonists such as collagen, ADP, thrombin, and epinephrine-induced aggregation of both platelet-rich plasma (PRP) and washed platelets preparations of human. Interestingly, fusaric acid showed biphasic effects only in thrombin-induced platelet aggregation of washed platelets, and at lower concentration (below 900âŠng) it activated platelet aggregation; however, in increased concentration (above 900âŠng) it inhibited the platelet aggregation of washed platelets. In addition, fusaric acid also inhibited the agonist ADP-induced platelet aggregation of washed platelet suspension but did not show biphasic effect. Further, fusaric acid did not induce the platelets to generate reactive oxygen species (ROS) that clearly suggests that the induction of platelet function could be the result of the fusaric acid-mediated receptor interaction but not through the morphological shape change.

Item Type: Article
Uncontrolled Keywords: article, human, priority journal, controlled study, reactive oxygen metabolite, in vitro study, Dose-Response Relationship, Drug, Humans, Cells, Cultured, Reactive Oxygen Species, plasma, adenosine diphosphate, adrenalin, collagen, thrombocyte aggregation, blood clotting, Blood Coagulation, Blood Coagulation Tests, hemostasis, Platelet Aggregation, thrombin, Thrombin, hemolysis, erythrocyte, Drug Interactions, thrombocyte count, blood clotting time, Blood Platelets, thrombocyte, thrombocyte activation, thrombocyte rich plasma, Cell Shape, Mycotoxins, thrombocyte function, Adenosine Diphosphate, Collagen, Epinephrine, Erythrocytes, fusaric acid, Fusaric Acid
Subjects: B Life Science > Biotechnology
C Chemical Science > Biochemistry
Divisions: Department of > Biochemistry
Department of > Biotechnology
Depositing User: Arshiya Kousar
Date Deposited: 19 Sep 2019 07:05
Last Modified: 19 Sep 2019 07:05
URI: http://eprints.uni-mysore.ac.in/id/eprint/8004

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