Synthesis and characterisation of new tetralone ester intermediates of podophyllotoxin analogues and their antifungal activity

Basavaraju, Y. B. and Raju, D. and Anupama, N. (2013) Synthesis and characterisation of new tetralone ester intermediates of podophyllotoxin analogues and their antifungal activity. International Journal of Pharmaceutical Sciences Review and Research, 21 (1). pp. 305-309. ISSN 0976-044X

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Abstract

Podophyllotoxin, one of the well-known naturally occurring lignan, has been used as the lead compound for the preparation of potent anticancer agents such as etoposide, tenoposide and etopophos. It also exhibits other biological activities. New tetralone ester intermediates of podophyllotoxin analogues were synthesised in very good yields by chalcone route. They were synthesized by introducing respectively with p-tolyl, p-fluorophenyl and cyclohexyl groups on podophyllotoxin was the transformation of the 3, 4, 5- trimethoxy group and also methylthio group was the transformation of the methylenedioxy group to study their structure activity relationship. All the synthesised products were characterized by spectral and elemental analysis data.

Item Type: Article
Uncontrolled Keywords: article, controlled study, drug screening, nonhuman, 2, unclassified drug, antifungal activity, drug synthesis, structure activity relation, 3, ester derivative, physical chemistry, concentration response, nystatin, chemical interaction, chemical modification, 4 tetrahydronaphthalene 2 carboxylate, ethyl 1 (4 fluorophenyl) 7 (methylthio) 4 oxo 1, ethyl 1 cyclohexyl 7 (methylthio) 4 oxo 1, ethyl 7 (methylthio) 4 oxo 1 4 tolyl 1, podophyllotoxin derivative, tetralone ester
Subjects: B Life Science > Botany
C Chemical Science > Chemistry
Divisions: Department of > Botany
Department of > Chemistry
Depositing User: Arshiya Kousar
Date Deposited: 18 Sep 2019 09:54
Last Modified: 18 Sep 2019 09:54
URI: http://eprints.uni-mysore.ac.in/id/eprint/7996

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