Synthesis of 2,5-disubstituted-1,3,4-oxadiazoles using ethyl oleate as precursor

Jayaroopa, P. and Ajay Kumar, K. and Vasanth Kumar, G. (2013) Synthesis of 2,5-disubstituted-1,3,4-oxadiazoles using ethyl oleate as precursor. International Journal of ChemTech Research, 5 (5). pp. 2516-2520. ISSN 0974-4290

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Abstract

Ethyl oleate (1) reacts with hydrazine hydrate to form stearic acid hydrazide (2), the reaction proceeds with the simultaneous reduction of 9,10 C=C bond of ethyl oleate. The stearic acid hydrazide formed on intermolecular cyclisation with different aliphatic acids, aromatic acids (3), or ethyl oleate (1) in the presence of phosphorus oxychloride forms 2,5-disubstituted 1,3,4-oxadiazoles (4) in good yield. The structure proofs of the product were confirmed by spectral studies and elemental analysis.

Item Type: Article
Uncontrolled Keywords: article, 1, 2, thin layer chromatography, unclassified drug, infrared spectroscopy, drug synthesis, 3, mass spectrometry, chemical reaction, 4 oxadiazole, 4 oxadiazole derivative, proton nuclear magnetic resonance, carbon nuclear magnetic resonance, liquid chromatography, stearic acid derivative, 5 disubstituted 1, 2 (4 aminophenyl) 5 heptadecyl 1, 2 (chloromethyl) 5 heptadecyl 1, 2 (heptadec 8 enyl) 5 heptadecyl 1, 2 benzyl 5 heptadecyl 1, 2 heptadecyl 5 (2 methylphenyl) 1, 2 heptadecyl 5 (4 nitrophenyl) 1, 2 heptadecyl 5 phenyl 1, 2 heptadecyl 5 styryl 1, heptadecyl 2 (2 hydroxyphenyl) 1, hydrazide, oleic acid ethyl ester, precursor
Subjects: C Chemical Science > Chemistry
Divisions: Yuvaraj college > Chemistry
Depositing User: Arshiya Kousar
Date Deposited: 21 Sep 2019 06:01
Last Modified: 21 Sep 2019 06:01
URI: http://eprints.uni-mysore.ac.in/id/eprint/7971

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