Synthesis and antimicrobial activity of 4, 5-dihydropyrazoline derivatives

Jayaroopa, P. and Ajay Kumar, K. (2013) Synthesis and antimicrobial activity of 4, 5-dihydropyrazoline derivatives. International Journal of Pharmacy and Pharmaceutical Sciences, 5 (4). pp. 431-433.

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In search of new potential antimicrobial agents, series of trisubstituted 4.5-dihydropyrazoline derivatives have been synthesized starting from chalcones. A mixture of 4-phenylbut-3-en-2-one (1, 0.001mmol), phenyl hydrazine hydrochloride (2a-g 0.001mmol) and sodium acetate (0.002mmol) in ethyl alcohol was stirred at room temperature for 1 hr to get trisubstituted 4,5-dihydropyrazoles (3a-g) in good yield. Spectral, X-ray diffraction and elemental analysis confirmed the structures of the products. The synthesised compounds have been evaluated in vitro for their antimicrobial activity. The results revealed that some compounds particularly with chloro substituents act as potential antimicrobial agents.

Item Type: Article
Uncontrolled Keywords: article, alcohol, controlled study, nonhuman, unclassified drug, acetic acid, Aspergillus flavus, Aspergillus niger, Bacillus subtilis, Candida albicans, drug synthesis, Escherichia coli, minimum inhibitory concentration, Salmonella typhimurium, structure analysis, X ray diffraction, 4, antimicrobial activity, ciprofloxacin, spectrophotometry, proton nuclear magnetic resonance, melting point, carbon nuclear magnetic resonance, pyrazoline derivative, amphotericin B, 5 dihydropyrazoline derivative, acetylphenylhydrazine, benzylideneacetone
Subjects: C Chemical Science > Chemistry
Divisions: Yuvaraj college > Chemistry
Depositing User: Arshiya Kousar
Date Deposited: 23 Sep 2019 10:22
Last Modified: 23 Sep 2019 10:22

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