Use of an oxidation reaction for the quantitative determination of albendazole with chloramine-T and acid dyes

Basaviah, K. and Prameela, H. C. (2003) Use of an oxidation reaction for the quantitative determination of albendazole with chloramine-T and acid dyes. Analytical Sciences, 19 (5). pp. 779-784. ISSN 1348-2246

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Abstract

One titrimetric and two spectrophotometric procedures have been reported for the determination of albendazole and its tablets. Using titrimetry, the drug was titrated directly with Chloramine-T under acidic conditions using a Methyl Orange indicator. The spectrophotometric procedures involve treating the sample solution with a measured excess of Chloramine-T in an acid medium, followed by an estimation of unreacted Chloramine-T by reacting with a fixed amount of either Methyl Orange or Indigo Carmine dye solution and measuring the absorbance at 510 nm or 610 nm. The stoichiometric ratio, which forms the basis for the calculations in titrimetry as well as the range of the applicability, are reported. The Beer's law range and sensitivity values for spectrophotometric procedures are included. The methods were applied to the determination of albendazole in tablets with satisfactory results.

Item Type:	Article
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	LA manjunath user
Date Deposited:	12 Sep 2019 05:16
Last Modified:	11 Dec 2019 10:11
URI:	http://eprints.uni-mysore.ac.in/id/eprint/7926

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