Ashkavand, Z. and Malekinejad, H. and Mirza Aghazadeh, A. and Aghazade Attari, J. and Vishwanath, B. S. (2013) Potentiality and safety assessment of combination therapy with silymarin and celecoxib in osteoarthritis of rat model. Biomedicine and Preventive Nutrition, 3 (3). pp. 209-212.
Full text not available from this repository. (Request a copy)Abstract
Osteoarthritis (OA) is a common form of arthritis leading to cartilage degeneration and inflammation. We used rat model to evaluate the protective effect of silymarin (SMN) as a known antioxidant agent individually and in combination with celecoxib (CLX) as a COX-2 inhibitor on MIA-induced arthritis. The rats were assigned into five groups (n= 6) as control, sham, and tests. The objective was to improve adverse events occurring with celecoxib in the treatment of osteoarthritis. The biochemical alterations and its recovery by silymarin and combination of silymarin and celecoxibe were assessed by measuring enzymatic and non-enzymatic mediators. In the present study, our data demonstrated the significant (P\textless. 0.001) elevated serum levels of hyaluronidase, C-reactive protein, 5-LOX and liver function enzymes, while both CLX and SMN reduced the level of these enzymatic and non-enzymatic mediators. Taken together, the study depicted the efficiency and protective role of combination of CLX with SMN in the treatment of OA. Thus it may be a safe compound to fight arthritis. © 2013 Elsevier Masson SAS.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | alanine aminotransferase, animal experiment, animal model, antiinflammatory activity, arachidonate 5 lipoxygenase, article, aspartate aminotransferase, C reactive protein, celecoxib, combination chemotherapy, controlled study, drug efficacy, drug safety, enzyme activity, enzyme blood level, hyaluronidase, liver function, liver toxicity, male, monotherapy, nonhuman, osteoarthritis, priority journal, protein blood level, rat, Rattus, silymarin |
| Subjects: | C Chemical Science > Biochemistry |
| Divisions: | Department of > Biochemistry |
| Depositing User: | Arshiya Kousar Library Assistant |
| Date Deposited: | 11 Sep 2019 05:43 |
| Last Modified: | 12 Jul 2022 06:56 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/7840 |
Actions (login required)
 |
View Item |
