In vitro antibacterial and antifungal evaluation of some benzophenone analogues

Al-Ghorbani, M. and Lakshmi Ranganatha, V. and Prashanth, T. and Bushra Begum, A. and Khanum, S. A. (2013) In vitro antibacterial and antifungal evaluation of some benzophenone analogues. Der Pharma Chemica, 5 (4). pp. 269-273. ISSN 0975-413X

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Abstract

Antibacterial and antifungal agents are widely used in the management of infectious disease but most of them have developed resistance to micro-organism. To overcome this problem and to lower the side effects, many approaches can be utilized. Benzophenone derivatives are reported to have the broad spectrum of biological activities. In the present study we have screened benzophenone derivatives 5a-k against six bacterial species viz gram positive (Bacillus subtilis and Staphylococcus aureus) and gram negative (Pseudomonas aeruginosa, Salmonella typhi, Proteus vulgaris, Shigella flexneri) bacteria. Also compounds 5a-k were tested with six fungal species viz (Candida albicans, Aspergillus niger, Fusarium solani, Aspergillus flavus, Botrytis cinerea, Candida krusei). The obtained results showed that the synthesized compounds 5a-k exhibited moderate to good activities against all the tested strains. Compounds 5a, 5c, 5d, 5f and 5g have shown good antibacterial and antifungal activities against selected strains.

Item Type:	Article
Uncontrolled Keywords:	(2 aroyl 4 methylphenoxy)acetamide, (2 aroyl 4 methylphenoxy)ethanoic acid, antibacterial activity, antifungal activity, article, Aspergillus flavus, Aspergillus niger, Bacillus subtilis, benzophenone derivative, Botrytis cinerea, Candida albicans, Candida krusei, concentration response, controlled study, drug screening, drug structure, drug synthesis, ethyl (2 aroyl 4 methylphenoxy)acetate, fluconazole, Fusarium solani, Gram negative bacterium, Gram positive bacterium, hydroxybenzophenone derivative, in vitro study, nonhuman, Proteus vulgaris, Pseudomonas aeruginosa, Salmonella typhi, Shigella flexneri, Staphylococcus aureus, streptomycin, structure activity relation, unclassified drug
Subjects:	C Chemical Science > Chemistry
Divisions:	Yuvaraj college > Chemistry
Depositing User:	Arshiya Kousar Library Assistant
Date Deposited:	09 Sep 2019 10:00
Last Modified:	09 Sep 2019 10:00
URI:	http://eprints.uni-mysore.ac.in/id/eprint/7830

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