Yathirajan, H. S. and Narasegowda, R. S. and Nagaraja, P. and Bolte, Michael (2005) A pseudopolymorph of valdecoxib. Acta Crystallographica Section E: Crystallographic Communications, 61 (1). o179-o181. ISSN 2056-9890
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Abstract
Valdecoxib, C16H14N2O3S, is a non-steroidal anti-inflammatory drug containing a planar isoxazole heterocycle which is substituted at the C atoms with two aromatic rings and a methyl group. In addition to one molecule of valdecoxib, there is half a molecule of ethyl methyl ketone in the asymmetric unit of the title compound [systematic name: 4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonamide ethyl methyl ketone hemisolvate], viz. C16H14N2O3S·0.5C4H8O. The crystal packing is stabilized by N-H...O hydrogen bonds. Apart from the orientation of the sulfonamide group, the conformation of the title compound agrees well with that of the recently published orthorhombic polymorph which does not contain any solvent.
| Item Type: | Article |
|---|---|
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Department of > Chemistry |
| Depositing User: | Manjula P Library Assistant |
| Date Deposited: | 09 Sep 2019 07:47 |
| Last Modified: | 09 Sep 2019 07:47 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/7821 |
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