Sildenafil citrate monohydrate

Yathirajan, H. S. and Nagaraj, B. and Nagaraja, P. and Bolte, Michael (2005) Sildenafil citrate monohydrate. Acta Crystallographica Section E: Crystallographic Communications, 61 (2). o489-o491. ISSN 2056-9890

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Sildenafil citrate is well known as Viagra for the treatment of erectile dysfuncion. In the title compound (systematic name: 1-{[3-(6,7-Di­hydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo­[4,3-d]­pyrimidin-5-yl)-4-ethoxy­phenyl]­sulfonyl}-4-methyl­piper­az­in­ium citrate monohydrate), C22H31N6O4S+·C6H7O7-·H2O, the pyrazolopyrimidone ring system and the benzene ring are almost coplanar, enabling an intramolecular hydrogen bond between the pyrazolopyrimidone NH group and the O atom of the ethoxy group. One of the N atoms of the piperazine ring is protonated and the citrate mol­ecule exists as an anion. The crystal packing is stabilized by several hydrogen bonds.

Item Type: Article
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: Manjula P Library Assistant
Date Deposited: 07 Sep 2019 07:38
Last Modified: 07 Sep 2019 07:38

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