Determination of felodipine in bulk drug and in tablets by high performance liquid chromatography

Basavaiah, K. and Chandrashekar, U. and Prameela, H. C. (2003) Determination of felodipine in bulk drug and in tablets by high performance liquid chromatography. Indian Journal of Chemical Technology, 10 (5). pp. 454-456. ISSN 0971-457X

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Abstract

A rapid assay procedure based on high-performance liquid chromatography (HPLC) has been developed for the specific determination of antihypertensive drug felodipine in pharmaceutical formulation (tablets). The HPLC determination was carried out on a reversed-phase C-18 (250x4.6 mm i.d) column using a mobile phase consisting of acetonitrile 20 mM aqueous ammonium acetate buffer of pH 4.5 (80+20) at a flow of 1.0 mL min(-1) with UV defection at 236 nm. Calibration graph was linear from 2.49 to 99.60 mug mL(-1). The method has been validated according to current guidelines including the assay of pharmacopoeial standard tablets. Recoveries ranged from 97.80 to 102.10%. The excipient present in the tablets did not interfere in the method. The described HPLC method is comparable in terms of accuracy and precision with that of a reported method.

Item Type: Article
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: LA manjunath user
Date Deposited: 07 Sep 2019 05:56
Last Modified: 11 Dec 2019 10:21
URI: http://eprints.uni-mysore.ac.in/id/eprint/7724

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