Enhancement in antimicrobial activity of 2-(phenyl)-3-(2-butyl-4-chloro-1H-imidazolyl)-5-butylate isoxazolidine

Sadashiva, M. P. and Mallesha, H. and Murthy, K. K. and Rangappa, K. S. (2005) Enhancement in antimicrobial activity of 2-(phenyl)-3-(2-butyl-4-chloro-1H-imidazolyl)-5-butylate isoxazolidine. Bioorganic & Medicinal Chemistry Letters, 15 (7). 1811 - 1814. ISSN 1464-3405

[img] Text (Full Text)
Enhancement in antimicrobial activity.pdf - Published Version
Restricted to Registered users only

Download (128kB) | Request a copy
Official URL: https://doi.org/10.1016/j.bmcl.2005.02.034


The trans rich isomer, 2-(phenyl)-3-(2-butyl-4-chloro-1H-imidazolyl)-5-butylate isoxazolidine A (>96 ee) was synthesized by the condensation of E isomer rich nitrone 4 (>98 ee) with butyl acrylate in an inert solvent. Obtained isoxazolidine was screened for its antifungal activity against Aspergillus niger, Cephalosporium acremonium, Fusarium moniliforme by using Nystatin as positive control. It was also tested for its antibacterial activity against Bacillus subtilis, Escherichia coli, and Staphylococcus aureus by using Streptomycin as positive control. Enhanced antifungal activity was observed in isoxazolidine of >96 ee compared to the isoxazolidine of >69 ee (B), and enhancement was not observed in antibacterial activity.

Item Type: Article
Uncontrolled Keywords: Antifungal activity, Synthesis, Nitrone, Isoxazolidine
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: Manjula P Library Assistant
Date Deposited: 06 Sep 2019 10:39
Last Modified: 06 Sep 2019 10:39
URI: http://eprints.uni-mysore.ac.in/id/eprint/7695

Actions (login required)

View Item View Item