Synthesis and antimicrobial activity of 5-[(4-aroyl) aryloxymethyl]-2-(4-methylphenylamino)-1,3,4-thiadiazoles and 5-[(4-aroyl) aryloxy methyl]-4-(4-methylphenyl)-3-mercapto-4H-1,2,4-triazoles

Sudha, B. S. and Shashikanth, S. and Khanum, S. A. (2003) Synthesis and antimicrobial activity of 5-[(4-aroyl) aryloxymethyl]-2-(4-methylphenylamino)-1,3,4-thiadiazoles and 5-[(4-aroyl) aryloxy methyl]-4-(4-methylphenyl)-3-mercapto-4H-1,2,4-triazoles. Indian Journal of Chemistry Section B-Organic Chemistry Including Medicinal Chemistry, 42 (10). pp. 2652-2656. ISSN 0975-0983

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Official URL: http://nopr.niscair.res.in/handle/123456789/21740

Abstract

Aroyl aryloxyacetic thiosemicarbazides 4a-d have been synthesized by the reaction of acid hydrazides 3a-d with p-tolyl isothiocyanate. The aroyl aryloxyacetic thiosemicarbazides 4a-d on intramolecular cyclization using conc.H2SO4 and 2N NaOH give 1,3,4-thiadiazoles 5a-d and 3-mercapto-4H-1,2,4-triazoles 6a-d, respectively. The structures of the synthesized compounds have been determined by their elemental analysis and spectral data. The synthesized compounds are evaluated for their antibacterial activity.

Item Type: Article
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: LA manjunath user
Date Deposited: 06 Sep 2019 06:22
Last Modified: 10 Dec 2019 09:25
URI: http://eprints.uni-mysore.ac.in/id/eprint/7679

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