Synthesis of benzoyl phenyl benzoates as effective inhibitors for phospholipase A2 and hyaluronidase enzymes

Khanum, S. A. and Murari, S. K. and Vishwanth, B. S. and Shashikanth, S. (2005) Synthesis of benzoyl phenyl benzoates as effective inhibitors for phospholipase A2 and hyaluronidase enzymes. Bioorganic & Medicinal Chemistry Letters, 15 (18). 4100 - 4104. ISSN 1464-3405

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Official URL: https://doi.org/10.1016/j.bmcl.2005.06.012

Abstract

Benzoylation of (hydroxy phenyl) phenyl methanone 2a–g to benzoyl phenyl benzoates 4a–g, a benzophenone analogue, was achieved in good yield. All the newly synthesized compounds were evaluated for their phospholipase A2 E.C. 3.1.1.4 and hyaluronidase E.C. 3.2.1.35 enzyme inhibitory activity in snake venom as source and their structure–activity relationship with respect to different groups is reported for the first time. The in vitro PLA2 enzyme inhibitory activity and in vivo anti-inflammatory activity studies of benzoyl phenyl benzoates are illustrated.

Item Type: Article
Uncontrolled Keywords: Phospholipase A inhibitor, Hyaluronidase inhibitor, Benzoyl phenyl benzoates
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: manjula User
Date Deposited: 05 Sep 2019 06:03
Last Modified: 05 Sep 2019 06:03
URI: http://eprints.uni-mysore.ac.in/id/eprint/7600

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