Synthesis and screening for acetylcholinesterase inhibitor activity of some novel 2-butyl-1,3-diaza-spiro4,4non-1-en-4-ones: Derivatives of irbesartan key intermediate

Kavitha, C. V. and Gaonkar, S. L. and Chandra, J. N. Narendra Sharath and Sadashiva, C. T. and Rangappa, K. S. (2007) Synthesis and screening for acetylcholinesterase inhibitor activity of some novel 2-butyl-1,3-diaza-spiro4,4non-1-en-4-ones: Derivatives of irbesartan key intermediate. Bioorganic & Medicinal Chemistry, 15 (23). 7391 - 7398. ISSN 1464-3391

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Official URL: https://doi.org/10.1016/j.bmc.2007.07.014

Abstract

The association of bioactive nucleus with other pharmacological agents is hoped to improve the efficacy of the treatment by combining the effects of different pharmacological mechanisms of action. Keeping this in view, a series of 2-butyl-1,3-diaza-spiro4,4non-1-en-4-one derivatives have been synthesized by interaction of 2-butyl-1,3-diaza-spiro4,4non-1-en-4-one with different bioactive aralkyl halides in presence of powdered potassium carbonate by two different methods viz., conventional and microwave irradiation. The yields under conventional and microwave irradiation methods were in the range of 60–65% and 80–90%, respectively. The structure elucidation of the new compounds has been carried out with the help of elemental analysis and spectral data. All the synthesized compounds have been screened for their efficacy as acetylcholinesterase (AChE) inhibitor. AChE inhibitory activity study was carried out by using Ellman colorimetric assay with neostigmine as a reference standard against targets from different species, such as pure electric eel AChE, human serum AChE, and rat brain AChE. Among the compounds synthesized, compounds 5a, 5b, 5j showed good inhibition against AChE.

Item Type: Article
Uncontrolled Keywords: 2-Butyl-1,3-diaza-spiro4,4non-1-en-4-one, Aralkyl halides, Irbesartan, Acetylcholinesterase inhibitors
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: MUL SWAPNA user
Date Deposited: 04 Sep 2019 10:02
Last Modified: 04 Sep 2019 10:02
URI: http://eprints.uni-mysore.ac.in/id/eprint/7550

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