EFFECTS OF CHLORPROMAZINE ON THE ENZYMATIC AND TOXIC PROPERTIES OF THE MOST BASIC PHOSPHOLIPASE A(2) FROM VIPERA-RUSSELLI SNAKE-VENOM

Babu, A. S. and Gowda, T. Veerabasappa (1995) EFFECTS OF CHLORPROMAZINE ON THE ENZYMATIC AND TOXIC PROPERTIES OF THE MOST BASIC PHOSPHOLIPASE A(2) FROM VIPERA-RUSSELLI SNAKE-VENOM. INFLAMMATION RESEARCH, 44 (8). pp. 340-344. ISSN 1023-3830

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Official URL: http://dx.doi.org/10.1007/BF01796265

Abstract

The effect of chlorpromazine on various biological activities of phospholipase A(2) VRV-PL-VIIIa from Vipera russelli snake venom was investigated. The drug inhibited the in vitro phospholipase A(2) activity of the enzyme by 55%. The ID50 was found to be 1.15 mu M. Increasing substrate concentration relieved the inhibition of phospholipase A(2) activity by the drug indicating probable interaction with the substrate. The drug totally quenched the fluorescence intensity of the enzyme. Chlorpromazine increased the LD(50) Of the enzyme by 1.6 fold. The drug also inhibited hemolytic and anticoagulant potencies but failed to inhibit edema inducing activity and myotoxicity of the enzyme.

Item Type: Article
Additional Information: Unmapped bibliographic data: DA - 1995/08// [EPrints field already has value set] LA - English [Field not mapped to EPrints]
Uncontrolled Keywords: CHLORPROMAZINE, INHIBITION, INTERACTION, PHOSPHOLIPASE A(2), SNAKE VENOM
Subjects: Agriculture Biological Sciences > Biochemistry
University of Mysore > PG Campuses > Manasagangotri, Mysore > Agriculture Biological Sciences > Biochemistry
Divisions: PG Campuses > Manasagangotri, Mysore > Biochemistry
Depositing User: Users 23 not found.
Date Deposited: 02 May 2013 08:57
Last Modified: 11 Sep 2013 06:04
URI: http://eprints.uni-mysore.ac.in/id/eprint/7505

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