Expeditious synthesis of 1,3,4-oxadiazole derivatives via sydnones

Kamble, Ravindra R. and Sudha, B. S. and Bhadregowda, D. G. (2008) Expeditious synthesis of 1,3,4-oxadiazole derivatives via sydnones. Journal of the Serbian Chemical Society, 73 (2). pp. 131-138. ISSN 1820-7421

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Official URL: https://doi.org/10.2298/JSC0802131K


The clean cyclization of chalcones (1a-c/2a-c) with hydrazine hydrate under microwave irradiation afforded pyrazolines derivatised with sydnone (3d-i/4d-i), which underwent 1,3-dipolar cyclo-addition with acetic anhydride to form pyrazolines appended with 1,3,4-oxadiazoles (5g-l/6g-l). The newly synthesized compounds were confirmed by spectral and elemental analyses. In comparison to classical heating, the results indicate that microwave irradiation affords higher yields, shorter reaction times (4-12 min) and cleaner reactions.

Item Type: Article
Subjects: C Chemical Science > Chemistry
Divisions: Yuvaraj college > Chemistry
Depositing User: Manjula P Library Assistant
Date Deposited: 03 Sep 2019 07:20
Last Modified: 03 Sep 2019 07:20
URI: http://eprints.uni-mysore.ac.in/id/eprint/7484

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