Isolation and characterization of process related impurities in anastrozole active pharmaceutical ingredient

Hiriyanna, S. G. and Basavaiah, K. (2008) Isolation and characterization of process related impurities in anastrozole active pharmaceutical ingredient. Journal of the Brazilian Chemical Society, 19 (3). pp. 397-404. ISSN 1678-4790

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Abstract

Three impurities ranging from 0.08%-0.12% by peak area in anastrozole active pharmaceutical ingredient were detected by simple isocratic reverse-phase high performance liquid chromatography (HPLC). These impurities were isolated by prep-HPLC and were characterized by LC-MS/MS, GCMS and NMR experimental data. Based on the results obtained from different spectroscopic experiments, these impurities have been characterized as 2,2�-(5-((4H-1,2,4-triazol-4-yl)methyl)-1,3-phenylene)bis(2-methylpropanenitrile) (Impurity I), 2,2�-(5-methyl-1,3-phenylene)bis(2-methylpropanenitrile) (Impurity II) and 2,2�-(5-(bromomethyl)-1,3-phenylene)bis(2-methyl-propanenitrile) (Impurity III).

Item Type:	Article
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	Manjula P Library Assistant
Date Deposited:	03 Sep 2019 05:45
Last Modified:	03 Sep 2019 05:45
URI:	http://eprints.uni-mysore.ac.in/id/eprint/7472

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