Umesha, K. B. and Rai, K. M. Lokanatha and Nayaka, Harish M. A. (2009) Antioxidant and antimicrobial activity of 5-methyl-2-(5-methyl-1,3-diphenyl-1h-pyrazole-4-carbonyl)-2,4-dihydro-pyrazol-3-one. International Journal of Biomedical Science, 5 (4). pp. 359-368.
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Abstract
cycloaddition of nitrile imines 4 generated in situ by the catalytic dehydrogenation of diphenyl hydrazones 3 using chloramine-t (cAt) as oxidant in glacial acetic acid with enolic form of ethyl acetoacetate 5 afforded Ethyl 3-aryl-5-methyl-1-phenyl-1H-pyrazol-4-carboxylate 6 in 80 yield. the said pyrazoles 6 refluxed with 80 hydrazine hydrate using absolute alcohol as solvent for about 2-3 hours to produce the respective 5-methyl-1,3-diphenyl-1H-pyrazole-4-carboxylic acid hydrazide 7. the alcoholic solution of pyrazole acid hydrazides on heating with ethyl acetoacetate 5 to give the 5-methyl-2-(5-methyl-1,3-diphenyl- 1H-pyrazole-4-carbonyl)-2,4-dihydro-pyrazol-3-one 8. The synthesized compounds were found to exhibit good antimicrobial and antioxidant activity as evaluated by 1,1-diphenyl-2-picryl Hydrazyl (DPPH) radical scavenging, reducing power and DNA protection assays.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | pyrazoles and antimicrobial and antioxidants |
| Subjects: | C Chemical Science > Chemistry D Physical Science > Sugar Technology |
| Divisions: | Department of > Chemistry PG Centre Mandya > Sugar Technology Yuvaraj college > Chemistry |
| Depositing User: | Users 19 not found. |
| Date Deposited: | 03 Sep 2019 05:31 |
| Last Modified: | 13 Jan 2023 10:46 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/7470 |
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