Antimicrobial properties of a non-toxic glycoprotein (WSG) from Withania somnifera (Ashwagandha)

Girish, K. S. and Machiah, K. D. and Ushanandini, S. and Harish Kumar, K. and Nagaraju, S. and Govindappa, M. and Vedavathi, M. and Kemparaju, K. (2006) Antimicrobial properties of a non-toxic glycoprotein (WSG) from Withania somnifera (Ashwagandha). Journal of Basic Microbiology, 46 (5). pp. 365-374. ISSN 1521-4028

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Abstract A monomeric glycoprotein with a molecular mass of 28 kDa in SDS-PAGE was isolated from the Withania somnifera root tubers. The protein designated WSG (Withania somnifera glycoprotein) demonstrated potent antimicrobial activity against the phytopathogenic fungi and bacteria tested. Antifungal effect has been demonstrated in that WSG exerts a fungistastic effect by inhibiting spore germination and hyphal growth in the tested fungi. WSG showed potent antifungal activity against Aspergillus flavus, Fusarium oxysporum, F. verticilloides and antibacterial activity against Clvibacter michiganensis subsp. michiganensis. WSG is an acidic, non-toxic (trypsin-chymotrypsin) protease inhibitor. These results encourage further studies of WSG as a potential therapeutic agent for its antifungal activity. (© 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)

Item Type: Article
Subjects: C Chemical Science > Biochemistry
Divisions: Department of > Biochemistry
Depositing User: LA manjunath user
Date Deposited: 30 Aug 2019 06:57
Last Modified: 30 Aug 2019 06:57

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