Synthesis and antimicrobial activity of novel 1,3-oxazolidine nucleoside analogues

Sriharsha, S. N. and Shashikanth, S. (2006) Synthesis and antimicrobial activity of novel 1,3-oxazolidine nucleoside analogues. Heterocyclic Communications, 12 (3). pp. 213-218. ISSN 2191-0197

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Abstract

The synthesis of novel 1,3-oxazolidine pyrimidine nucleoside analogues are described. These analogues are all derived from the key stereochemically defined intermediate N-tert-butoxy-carbonyl-2-hydroxymethyl-1,3-oxazolidine-4-ol which was accessible in 57% yield. starting from L-serine methylester hydrochloride. The heterocyclic bases eg; uracil, thymine etc are efficiently introduced onto the 1,3-oxazolidine by the Vorbruggen procedures. The antimicrobial activity of novel 1,3-okazolidine nucleoside analogues are highlighted. The compounds 7d and 7e showed significant activity against bacteria and fungus.

Item Type:	Article
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	LA manjunath user
Date Deposited:	30 Aug 2019 06:27
Last Modified:	11 Dec 2019 11:10
URI:	http://eprints.uni-mysore.ac.in/id/eprint/7374

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