Redetermination of dihydro-artemisinin at 103(2)K

Jasinski, J. P. and Butcher, Ray J. and Yathirajan, H. S. and Narayana, B. and Sreevidya, T. V. (2008) Redetermination of dihydro-artemisinin at 103(2)K. Acta Crystallographica Section E, 64 (1). o89-o90. ISSN 1600-5368

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Tthe structure of the title compound, Csb 15Hsb 24Osb 5, has been redetermined at 103(2)K, with much improved precision. The title compound was first reported by Luo, Yeh, Brossi, Flippen-Anderson & Gillardi it Helv. Chim. Acta (1984). bf 67, 1515-1522. It is a derivative of the anti-malaria compound artemisinin and consists primarily of three substituted ring systems fused together. A cyclo-hexane ring (with a distorted chair conformation), is fused to a tetra-hydro-pyran group (also with a distorted chair conformation), and is adjacent to an oxacyclo-heptane unit containing an endoperoxide bridge. This gives the mol-ecule a unique three-dimensional arrangement. The crystal packing is stabilized by inter-molecular C-Hcdots O and O-Hcdots O inter-actions between an H atom from the cyclo-hexane ring and an O atom from the endoperoxide bridge, as well as between the hydroxyl H atom and an O atom from a tetra-hydro-pyran ring.

Item Type: Article
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: Manjula P Library Assistant
Date Deposited: 30 Aug 2019 05:18
Last Modified: 11 Jul 2022 09:49

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