Redetermination of dihydro-artemisinin at 103(2)K

Jasinski, J. P. and Butcher, Ray J. and Yathirajan, H. S. and Narayana, B. and Sreevidya, T. V. (2008) Redetermination of dihydro-artemisinin at 103(2)K. Acta Crystallographica Section E, 64 (1). o89-o90. ISSN 1600-5368

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Abstract

Tthe structure of the title compound, Csb 15Hsb 24Osb 5, has been redetermined at 103(2)K, with much improved precision. The title compound was first reported by Luo, Yeh, Brossi, Flippen-Anderson & Gillardi it Helv. Chim. Acta (1984). bf 67, 1515-1522. It is a derivative of the anti-malaria compound artemisinin and consists primarily of three substituted ring systems fused together. A cyclo-hexane ring (with a distorted chair conformation), is fused to a tetra-hydro-pyran group (also with a distorted chair conformation), and is adjacent to an oxacyclo-heptane unit containing an endoperoxide bridge. This gives the mol-ecule a unique three-dimensional arrangement. The crystal packing is stabilized by inter-molecular C-Hcdots O and O-Hcdots O inter-actions between an H atom from the cyclo-hexane ring and an O atom from the endoperoxide bridge, as well as between the hydroxyl H atom and an O atom from a tetra-hydro-pyran ring.

Item Type:	Article
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	Manjula P Library Assistant
Date Deposited:	30 Aug 2019 05:18
Last Modified:	11 Jul 2022 09:49
URI:	http://eprints.uni-mysore.ac.in/id/eprint/7345

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