A second polymorph of β-arteether.

Jasinski, Jerry P. and Butcher, Ray J. and Yathirajan, H. S. and Narayana, B. and Sreevidya, T. V. (2008) A second polymorph of β-arteether. Acta Crystallogr Sect E, 13 (64). o585. ISSN 1600-5368

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Official URL: https://doi.org/10.1107/S1600536807062812.


The crystal structure of the title compound, C(17)H(28)O(5), reported here is a polymorph of the structure first reported by El-Feraly, Al-Yahya, Orabi, McPhail & McPhail [J. Nat. Prod. (1992). 55, 878-883]. It is a derivative of the anti-malaria compound artemisinin and consists primarily of three substituted ring systems fused together. A cyclo-hexane ring (distorted chair conformation) fused to a tetra-hydro-pyran group (distorted chair) is adjacent to an oxacyclo-heptane unit containing an endo-peroxide bridge, giving the mol-ecule its particular three-dimensional arrangement. The crystal packing is stabilized by inter-molecular C-H⋯O inter-actions between an O atom from the endo-peroxide bridge and H atoms from both the cyclo-hexane and seven-membered oxacyclo-heptane fused rings, as well as between an O atom and H atom from adjacent tetra-hydro-pyran rings. The two polymorphs have the same space group and similar cell parameters for the a and b axes, but significantly different values for the c axis.

Item Type: Article
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: Manjula P Library Assistant
Date Deposited: 29 Aug 2019 10:24
Last Modified: 27 Sep 2019 10:00
URI: http://eprints.uni-mysore.ac.in/id/eprint/7336

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