Sunil Kumar, Y. C. and Malviya, Manish and Narendra Sharath Chandra, J. N. and Kavitha, C. V. and Thimmegowda, N. R. and Subhash, M. N. and Rangappa, K. S. (2009) Effect of novel N-arylurea- substituted 3-morpholino arecoline derivatives as muscarinic receptor 1 agonists in Alzheimer's dementia models. Arkivoc (9). pp. 45-56. ISSN 1551-7012
Full text not available from this repository. (Request a copy)Abstract
The cholinergic hypothesis of Alzheimer's disease has spurred the development of numerous compounds aimed at increasing central cholinergic neurotransmission. Symptomatic treatment can be given by cholinomimetics with the pharmacological profile of muscarinic receptor 1 (M1 receptor) agonist and/or acetylcholineesterase (AChE) inhibitors. Novel bioactive six-membered N-arylurea-substituted 3-morpholino arecoline derivatives were synthesized by N-benzyl aminoethanol coupling with alpha-bromoacetylpyridine followed by reduction and cyclization. Five of the derivatives showed high M1 receptor binding affinity in vitro and elicited beneficial effects in in vivo memory and learning models in rats.
| Item Type: | Article |
|---|---|
| Additional Information: | 5th Eurasian Conference on Heterocyclic Chemistry, Kuwait Univ, Kuwait City, KUWAIT, MAR 01-06, 2008 |
| Uncontrolled Keywords: | Alzheimer's diseases; M1 agonist; morpholino arecolines; displacement assay; rat brain |
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Department of > Chemistry |
| Depositing User: | Users 19 not found. |
| Date Deposited: | 29 Aug 2019 05:46 |
| Last Modified: | 29 Aug 2019 05:46 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/7293 |
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