Vinaya, K. and Kavitha, R. and Ananda Kumar, C. S. and Benaka Prasad, S. B. and Chandrappa, S. and Deepak, S. A. and Nanjunda Swamy, S. and Umesha, S. and Rangappa, K. S. (2009) Synthesis and antimicrobial activity of 1-benzhydryl-sulfonyl-4-(3-(piperidin-4-yl) propyl)piperidine derivatives against pathogens of Lycopersicon esculentum: A structure-activity evaluation study. Archives of Pharmacal Research, 32 (1). pp. 33-41. ISSN 1976-3786
Full text not available from this repository. (Request a copy)Abstract
Several 1-benzhydryl-sulfonyl-4-(3-(piperidin-4-yl)propyl)piperidine derivatives 8(a-j) were prepared by the treatment of substituted benzhydryl chlorides with 4-(3-(piperidin-4-yl)propyl)piperidine followed by N-sulfonation with sulfonyl chlorides in the presence of dry methylene dichloride and triethyl amine. The synthesized compounds were characterized by H-1-NMR, IR, and elemental analysis. All the synthesized compounds were evaluated in vitro for their efficacy as antimicrobial agents by artificial inoculation technique against standard strains of two important bacterial viz., Xanthomonas axonopodis pv. vesicatoria and Ralstonia solanacearum as well as and two fungal pathogens namely Alternaria solani and Fusarium solani of tomato plants. We have briefly investigated the structure-activity relation studies and reveal that the nature of substitutions on benzhydryl ring and sulfonamide ring influences the antibacterial activity. Among the synthesized new compounds 8b, 8d, 8g, 8h, 8i, and 8j were showed significant potent antimicrobial activities compared to the standard drugs Chloramphenicol, Mancozeb.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Benzhydryl chloride; 4-(3-(Piperidin-4-yl)propyl)piperidine; Sulfonyl chlorides; Lycopersicon esculentum; Structure activity relationship; Antimicrobial activity |
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Department of > Chemistry |
| Depositing User: | Users 19 not found. |
| Date Deposited: | 29 Aug 2019 05:42 |
| Last Modified: | 29 Aug 2019 05:42 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/7292 |
Actions (login required)
 |
View Item |
