Benzofuranyl esters: synthesis, crystal structure determination, antimicrobial and antioxidant activities

Kumar, C. S. C. and Then, Li Yee and Chia, Tze Shyang and Chandraju, S. and Win, Yip-Foo and Sulaiman, S. F. and Hashim, N. S. and Ooi, K. L. and Quah, C. K. and Fun, Hoong-Kun (2015) Benzofuranyl esters: synthesis, crystal structure determination, antimicrobial and antioxidant activities. MOLECULES, 20 (9). pp. 16566-16581. ISSN 1420-3049

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Official URL: http://doi.org/10.3390/molecules200916566

Abstract

A series of five new 2-(1-benzofuran-2-yl)-2-oxoethyl 4-(un/substituted)benzoates 4(a-e), with the general formula of C8H5O(C=O)CH2O(C=O)C6H4X, X = H, Cl, CH3, OCH3 or NO2, was synthesized in high purity and good yield under mild conditions. The synthesized products 4(a-e) were characterized by FTIR, H-1-, C-13- and H-1-C-13 HMQC NMR spectroscopic analysis and their 3D structures were confirmed by single-crystal X-ray diffraction studies. These compounds were screened for their antimicrobial and antioxidant activities. The tested compounds showed antimicrobial ability in the order of 4b < 4a < 4c < 4d < 4e and the highest potency with minimum inhibition concentration (MIC) value of 125 mu g/mL was observed for 4e. The results of antioxidant activities revealed the highest activity for compound 4e (32.62% +/- 1.34%) in diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, 4d (31.01% +/- 4.35%) in ferric reducing antioxidant power (FRAP) assay and 4a (27.11% +/- 1.06%) in metal chelating (MC) activity.

Item Type: Article
Uncontrolled Keywords: benzofuran; spectroscopic analysis; antimicrobial; antioxidant; XRD; substituent
Subjects: D Physical Science > Sugar Technology
Divisions: PG Centre Mandya > Sugar Technology
Depositing User: Shrirekha N
Date Deposited: 31 May 2019 05:50
Last Modified: 01 Jun 2019 11:37
URI: http://eprints.uni-mysore.ac.in/id/eprint/727

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