Evaluation and studies on the structural impact of 3-Aryl-5-(4-Methoxyphenyl)-4,5-Dihydroisoxazole-4-Carbonitriles on their biological activities

Jayaroopa, P. and Vasanth Kumar, G. and Renuka, N. and Akshatha, K. N. and Mahadevamurthy, S. and Ajay Kumar, K. and Jayaroopa (2012) Evaluation and studies on the structural impact of 3-Aryl-5-(4-Methoxyphenyl)-4,5-Dihydroisoxazole-4-Carbonitriles on their biological activities. Der Pharmacia Lettre, 4 (5). pp. 1685-1691. ISSN 0975-5071

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Abstract

In present study, a series of isoxazole derivatives was synthesized and evaluated for antibacterial and antifungal activities by disc diffusion method using different bacterial and fungal strains. Some compounds of the series exhibited promising antibacterial and antifungal activity compared to standard drugs. The minimum inhibitory concentration (MIC’s) was determined against each organism. The compounds were tested for their antioxidant activity and reducing power ability. Free radicals play an important role in various pathological and xenotoxic effects so antioxidant may have protective role in these pathological conditions. Based on the results of an antimicrobial, anti-oxidant study, the effect of substitution on the activity and possible structure activity relationship of the compounds for their antioxidant activity is presented

Item Type: Article
Subjects: C Chemical Science > Chemistry
Divisions: Yuvaraj college > Chemistry
Depositing User: MUL SWAPNA user
Date Deposited: 28 Aug 2019 10:15
Last Modified: 28 Aug 2019 10:15
URI: http://eprints.uni-mysore.ac.in/id/eprint/7264

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