Snake venom hyaluronidase:a therapeutic target

Kemparaju, K. and Girish, K. S. (2006) Snake venom hyaluronidase:a therapeutic target. Cell Biochemistry and Function, 24 (1). pp. 7-12. ISSN 1099-0844

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Abstract The diffusion of toxins from the site of a bite into the circulation is essential for successful envenomation. Degradation of hyaluronic acid in the extracellular matrix (ECM) by venom hyaluronidase is a key factor in this diffusion. Hyaluronidase not only increases the potency of other toxins but also damages the local tissue. In spite of its important role, little attention has been paid to this enzyme. Hyaluronidase exists in various isoforms and generates a wide range of hyaluronic acid degradation products. This suggests that beyond its role as a spreading factor venom hyaluronidase deserves to be explored as a possible therapeutic target for inhibiting the systemic distribution of venom and also for minimizing local tissue destruction at the site of the bite. Copyright © 2005 John Wiley & Sons, Ltd.

Item Type: Article
Uncontrolled Keywords: snake venom, hyaluronidase, spreading factor, hyaluronic acid, extracellular matrix
Subjects: C Chemical Science > Biochemistry
Divisions: Department of > Biochemistry
Depositing User: lpa manjunath user
Date Deposited: 28 Aug 2019 09:58
Last Modified: 28 Aug 2019 09:58

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