Ananda Kumar, C. S. and Murthy, K. and Sadashiva, M. P. and Vinaya, M. K. and Thimmegowda, N. R. and Benaka Prasad, S. B. and Chandrappa, S. and Rangappa, K. S. (2009) Synthesis and in vitro antimicrobial activity of medicinally important novel n-alkyl, n-aryl and urea derivatives of 1-benzhydryl piperizine: a structure-activity relationship study. Letters in Drug Design & Discovery, 6 (2). pp. 146-154. ISSN 1875-628X
Full text not available from this repository. (Request a copy)Abstract
Novel 1-benzhydryl piperazine derivatives 7(a-k) and 8(a-i) were synthesised in order to determine their antimicrobial activity and possible structure-activity relationships to improve the efficacy. Their chemical structures were confirmed by H-1 NMR, IR and elemental analysis. All the compounds were screened for their in vitro antibacterial activity against Bacillus subtilis, Escherichia coli and Staphylococcus aureus by using Streptomycin as positive control and antifungal activity against Aspergillus niger, Cephalosporium acremonium and Fusarium moniliforme by using Nystatin as positive control. Among the synthesized novel compounds 7h, 7k, 8g, 8h and 8i showed potent antimicrobial activities compared to the standard drugs. The SAR studies reveals that, both linkage and substituents on phenyl ring are responsible for the antimicrobial activity for these class of agents.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 1-benzhydryl piperazine derivatives; alkyl halides; aryl halides; isocyanates; minimum inhibitory concentration; antimicrobials |
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Department of > Chemistry |
| Depositing User: | Users 19 not found. |
| Date Deposited: | 28 Aug 2019 06:42 |
| Last Modified: | 15 Jul 2022 09:53 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/7224 |
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