Chandrappa, S. and Vinaya, K. and Srikanta, B. M. and Ananda Kumar, C. S. and Thimmegowda, N. R. and Ranganatha, S. R. and Shylaja Dharmesh, M. and Rangappa, K. S. (2009) Novel n-substituted thiazolidinones as proton pump inhibitors and potent anti-ulcer agents: sar study. Letters in Drug Design & Discovery, 6 (2). pp. 101-106. ISSN 1875-628X
Full text not available from this repository. (Request a copy)Abstract
A series of N-substituted thiazolidinone derivatives 5(a-j) was synthesized in good yield. All the compounds were screened for their in vitro H+, K+-ATPase inhibitory activity. The structures of the synthesized compounds were confirmed by the spectral data. Compounds 5d, 5e, 5f and 5c showed potential H+, K+-ATPase blocking activities, when compared to standard drug Lansoprazole. Structure-activity relationship studies, with various chemical groups, revealed that position and nature of the substitution on the N-thiazolidinones are crucial for H+, K+-ATPase inhibitory activity.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Thiazolidinone; 5-Formyl-2-methoxybenzoic acid; Alkyl halides; Anti-ulcer; Peptic ulcer; H+; K+-ATPase enzyme |
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Department of > Chemistry |
| Depositing User: | Users 19 not found. |
| Date Deposited: | 28 Aug 2019 06:29 |
| Last Modified: | 28 Aug 2019 06:29 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/7223 |
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