Antiangiogenic and proapoptotic activities of allyl isothiocyanate inhibit ascites tumor growth in vivo

Akhilesh Kumar and Saritha D'Souza, S. and Tickoo, Sanjay and Bharathi Salimath, P. and Singh, H. B. (2009) Antiangiogenic and proapoptotic activities of allyl isothiocyanate inhibit ascites tumor growth in vivo. Integrative Cancer Therapies, 8 (1). pp. 75-87. ISSN 1552-695X

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Official URL: http://doi.org/10.1177/1534735408330716

Abstract

The authors investigate the antiangiogenic and proapoptotic effects of mustard essential oil containing allyl isothiocyanate (AITC) and explore its mechanism of action on Ehrlich ascites tumor (EAT) cells. Swiss albino mice transplanted with EAT cells were used to study the effect of AITC. AITC was effective at a concentration of 10 pm as demonstrated by the inhibition of proliferation of EAT cells when compared with the normal HEK293 cells. It significantly reduced ascites secretion and tumor cell proliferation by about 80% and inhibited vascular endothelial growth factor expression in tumor-bearing mice in vivo. It also reduced vessel sprouting and exhibited potent antiangiogenic activity in the chorioallantoic membrane and cornea of the rat. AITC arrested the growth of EAT cells by inducing apoptosis and effectively arrested cell cycle progression at the G1 phase. The results clearly Suggest that AITC inhibits tumor growth by both antiangiogenic and proapoptotic mechanisms.

Item Type: Article
Uncontrolled Keywords: antiangiogenesis; essential oils; apoptosis; allyl isothiocyanate; vascular endothelial growth factor; Ehrlich ascites tumor; caspase-activated DNases
Subjects: B Life Science > Biotechnology
Divisions: Department of > Biotechnology
Depositing User: Shrirekha N
Date Deposited: 28 Aug 2019 05:47
Last Modified: 28 Aug 2019 05:47
URI: http://eprints.uni-mysore.ac.in/id/eprint/7198

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