Influence of advanced age of maternal grandmothers on down syndrome

Malini, S. S. and Ramachandra, N. B. (2006) Influence of advanced age of maternal grandmothers on down syndrome. BMC Medical Genetics, 7 (1). p. 4. ISSN 1471-2350

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Down syndrome (DS) is the most common chromosomal anomaly associated with mental retardation. This is due to the occurrence of free trisomy 21 (92--95%), mosaic trisomy 21 (2--4%) and translocation (3--4%). Advanced maternal age is a well documented risk factor for maternal meiotic nondisjunction. In India three children with DS are born every hour and more DS children are given birth to by young age mothers than by advanced age mothers. Therefore, detailed analysis of the families with DS is needed to find out other possible causative factors for nondisjunction.

Item Type: Article
Subjects: B Life Science > Zoology
Divisions: Department of > Zoology
Depositing User: LA manjunath user
Date Deposited: 28 Aug 2019 05:00
Last Modified: 11 Oct 2019 05:50

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