Anti-tumor and proapoptotic effect of novel synthetic benzophenone analogues in Ehrlich ascites tumor cells

Prabhakar, B. T. and Shaukath Ara Khanum and Jayashree, K. and Bharathi P. Salimath and Shashikanth, S. (2006) Anti-tumor and proapoptotic effect of novel synthetic benzophenone analogues in Ehrlich ascites tumor cells. Bioorganic & Medicinal Chemistry, 14 (2). 435 - 446. ISSN 1464-3391

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Abstract

A series of substituted benzophenone analogues, (2-aroyl-4-methylphenoxy)acetamides 4a–e, have been synthesized via three-step synthesis sequence beginning with the 2-hydroxybenzophenones 1a–e in excellent yield. 1a–e on reaction with ethyl chloroacetate afford ethyl (2-aroyl-4-methylphenoxy)acetates 2a–e which on alkaline hydrolysis afforded (2-aroyl-4-methylphenoxy)ethanoic acid 3a–e. Compounds 3a–e on condensation with p-chloroaniline furnished benzophenone analogues 4a–e. In the present report, we investigated the anti-tumor and proapoptotic effect of benzophenones in Ehrlich ascites tumor (EAT) cells. Treatment of benzophenones in vivo resulted in inhibition of proliferation of EAT cells and ascites formation. Further, we demonstrate that the induction of apoptosis in EAT cells is mediated through activation of caspase-3. These results suggest a further possible clinical application of these synthetic compounds as potent anti-tumor and proapoptotic compounds.

Item Type:	Article
Uncontrolled Keywords:	Benzophenones, EAT cells, Anti-tumor, Apoptosis, Caspases
Subjects:	B Life Science > Botany
Divisions:	Department of > Botany
Depositing User:	LA manjunath user
Date Deposited:	27 Aug 2019 11:33
Last Modified:	20 Jun 2022 10:34
URI:	http://eprints.uni-mysore.ac.in/id/eprint/7173

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