Khanum, Shaukath Ara and Girish, V. and Suparshwa, S. S. and Khanum, N. F. (2009) Benzophenone-N-ethyl piperidine ether analogues-synthesis and efficacy as anti-inflammatory agent. Bioorganic & Medicinal Chemistry Letters, 19 (7). pp. 1887-1891. ISSN 0960-894X
Full text not available from this repository. (Request a copy)Abstract
A sequence of substituted benzophenone-N-ethyl piperidine ether analogues has been synthesized and evaluated as orally active anti-inflammatory agents with reduced side effects. The anti-inflammatory and ulcerogenic activities of the compounds were compared with naproxen, indomethacin, and phenylbutazone. These analogues showed an interesting anti-inflammatory activity in carrageenan-induced foot pad edema assay. In the air-pouch test, some of the analogues reduced the total number of leukocytes of the exudate, which indicates inhibition of prostaglandin production. Side effects of the compounds were examined on gastric mucosa, in the liver and stomach. None of the compounds illustrated significant side effects compared with standard drugs like indomethacin and naproxen. (C) 2009 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Benzophenone-N-ethyl piperidine ethers; Anti-inflammatory activity |
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Department of > Chemistry Yuvaraj college > Chemistry |
| Depositing User: | Users 19 not found. |
| Date Deposited: | 27 Aug 2019 05:19 |
| Last Modified: | 11 Dec 2019 06:24 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/7090 |
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