Angiogenic and proliferative effects of the cytokine VEGF in ehrlich ascites tumor cells is inhibited by glycyrrhiza glabra

Sheela, M. L. and Ramakrishna, M. K. and Salimath, Bharathi P. (2006) Angiogenic and proliferative effects of the cytokine VEGF in ehrlich ascites tumor cells is inhibited by glycyrrhiza glabra. International Immunopharmacology, 6 (3). 494 - 498. ISSN 1878-1705

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Official URL: https://doi.org/10.1016/j.intimp.2005.07.002

Abstract

Blood vessel plays a crucial role in solid tumor development. It has been suggested that blocking of angiogenesis and the action of the cytokine VEGF could be possible in cancer therapy. In a screen for naturally occurring angiogenic inhibitors, we have identified an extract from the roots of Glycyrrhiza glabra, which has potent antiangiogenic and antitumor activity. The aqueous extract inhibits the in vivo and in vitro proliferation of Ehrlich ascites tumor cells. The angioinhibitory activity of G. glabra was confirmed by its inhibition of angiogenesis in in vivo assays, peritoneal and chorioallantoic membrane assay. Reduction in the levels of the cytokine VEGF and microvessel density count in the peritoneum of mice treated with G. glabra indicated that the plant extract decreased VEGF production and the cytokine induced neovascularization. Our results suggest that the extract from the roots of G. glabra may be a potential supplemental source for cancer therapy.

Item Type: Article
Uncontrolled Keywords: , Cytokine VEGF, Angiogenesis, Ehrlich ascites tumor (EAT)
Subjects: B Life Science > Botany
Divisions: Department of > Botany
Depositing User: lpa manjunath user
Date Deposited: 26 Aug 2019 08:00
Last Modified: 27 Aug 2019 04:27
URI: http://eprints.uni-mysore.ac.in/id/eprint/7051

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