Spectrophotometric determination of some phenothiazine drugs using chloramine-T-iodine-starch

Revanasiddappa, H. D. and Veena, M. A. (2008) Spectrophotometric determination of some phenothiazine drugs using chloramine-T-iodine-starch. Journal of Analytical Chemistry, 63 (2). pp. 140-144. ISSN 1061-9348

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Abstract

A simple, accurate, and sensitive spectrophotometric method for the determination of promethazine hydrochloride (PMH), prochlorperazine maleate (PCPM), trifluoperazine hydrochloride (TFPH), trimeperazine tartrate (TMT), fluphenazine dihydrochloride (FH), and trifluopromazine hydrochloride (TPH) is described. The method is based on the oxidation of the studied drugs by a known excess of chloramine-T in a hydrochloric acid medium and subsequent determination of the unreacted oxidant by interacting it with iodide in the same acid medium. Liberated iodine subsequently reacts with starch to form a stable starch-iodine complex. The reacted oxidant corresponds to the drug content. The colored complex exhibits a maximum absorption at 590 nm. The apparent molar absorptivity and Sandell sensitivity values are in the range 4.07 × 104 − 1.18 × 105 L/mol cm and 45.00−95.00 ng/cm2, respectively. The proposed method has been applied to the assay of phenothiazine drugs in pure and dosage forms. The reliability of the analysis was established using parallel determination by the reference method.

Item Type:	Article
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	Manjula P Library Assistant
Date Deposited:	26 Aug 2019 07:51
Last Modified:	26 Aug 2019 07:51
URI:	http://eprints.uni-mysore.ac.in/id/eprint/7044

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