Synthesis of pharmaceutically important condensed heterocyclic 4,6-disubstituted-1,2,4-triazolo-1,3,4-thiadiazole derivatives as antimicrobials

Nanjunda Swamy, S. and Basappa and Priya, B. S. and Prabhuswamy, B. and Doreswamy, B. H. and Shashidhara Prasad, J. and Rangappa, K. S. (2006) Synthesis of pharmaceutically important condensed heterocyclic 4,6-disubstituted-1,2,4-triazolo-1,3,4-thiadiazole derivatives as antimicrobials. European Journal of Medicinal Chemistry, 41 (4). 531 - 538. ISSN 1768-3254

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Abstract

The two series of 4,6-disubstituted 1,2,4-triazolo-1,3,4-thiadiazole derivatives 2(a–e) and 3(a–e) were synthesized and characterized using IR, 1H-NMR, CHNS analysis and by single crystal X-ray crystallographic studies. The compound 6-(2-chloro-phenyl)-3-ethyl-1,2,4triazole3,4-bthiadiazole 2b has been characterized by single crystal X-ray diffraction method. The compound crystallizes in monoclinic space group P21/c with a cell parameters a=11.879(1) Å, b=15.112(2) Å, c=13.95(2) Å, Z=8 and the final R factor is R1=0.0524. The structure exhibits both intra and intermolecular hydrogen bonds. The title compounds were checked for their efficacy as antimicrobials in vitro. Compounds 2b, 2c, 2d, 3b, 3c and 3d showed significant inhibition against all the strains tested, when compared to standard drugs.

Item Type:	Article
Uncontrolled Keywords:	1,2,4-Triazolo-1,3,4-thiadiazole, Antimicrobials, Intra/inter-molecular hydrogen bonds, Crystal structure
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	LA manjunath user
Date Deposited:	26 Aug 2019 05:47
Last Modified:	11 Dec 2019 11:18
URI:	http://eprints.uni-mysore.ac.in/id/eprint/7005

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